Antibacterial Mechanisms of Polymyxin and Bacterial Resistance
نویسندگان
چکیده
منابع مشابه
Antibacterial Mechanisms of Polymyxin and Bacterial Resistance
Multidrug resistance in pathogens is an increasingly significant threat for human health. Indeed, some strains are resistant to almost all currently available antibiotics, leaving very limited choices for antimicrobial clinical therapy. In many such cases, polymyxins are the last option available, although their use increases the risk of developing resistant strains. This review mainly aims to ...
متن کاملMechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The reintroduction of polymyxins for antimicrobial therapy has been followed by an increase in reports of resistance among Gram-negative bacteria. Some bacteria, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and ...
متن کاملOverview on Mechanisms of Antibacterial Resistance
Currently antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Antibiotics were discovered in the middle of the nineteenth century and brought down the threat of infectious diseases which had devastated the human race. However, soon after the discovery of penicillin in 1940, a number of tr...
متن کاملMolecular Mechanisms of Antibacterial Multidrug Resistance
Treatment of infections is compromised worldwide by the emergence of bacteria that are resistant to multiple antibiotics. Although classically attributed to chromosomal mutations, resistance is most commonly associated with extrachromosomal elements acquired from other bacteria in the environment. These include different types of mobile DNA segments, such as plasmids, transposons, and integrons...
متن کاملAntifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.
The increased use of antibacterial and antifungal agents in recent years has resulted in the development of resistance to these drugs. The significant clinical implication of resistance has led to heightened interest in the study of antimicrobial resistance from different angles. Areas addressed include mechanisms underlying this resistance, improved methods to detect resistance when it occurs,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/679109